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Dimethyl sulphoxide, or DMSO for short, is an organic sulphur compound that is used in many areas due to its remarkable chemical and physical properties. However, its inconspicuous appearance belies its impressive effectiveness and versatility.
What makes DMSO so special is its ability to penetrate the skin very quickly. Once applied to the skin, DMSO begins to work immediately by penetrating the upper layers of the skin and making its way to the deeper tissues. It is this ability to quickly reach deeper areas of the body that makes DMSO so valuable for therapeutic purposes.
Once in the deeper tissue layers, DMSO unfolds its effect by acting on the inflamed tissue. It helps to alleviate inflammatory processes and reduce the release of pain-causing substances in the body. In this way, pain and swelling can be significantly reduced. For those suffering from chronic pain, such as the persistent and often debilitating pain of arthritis, DMSO can provide significant relief.
DMSO is also effective for acute pain after injuries such as bruises, strains or other muscle and tissue damage. Due to its analgesic and anti-inflammatory effects, it can promote the healing process and shorten the time the body needs to recover. People who use DMSO often report a faster return to normal activities and an improvement in their quality of life.
Due to its ability to combat not only superficial but also deep-seated pain, DMSO is a versatile agent in the treatment of pain. Due to its penetrating ability, DMSO can also serve as a carrier for other therapeutic agents by facilitating their absorption and distribution in the desired area. This synergistic property of DMSO can increase the effectiveness of additional treatment methods and thus contribute to more comprehensive pain management.
Pain relief is one of the most outstanding and frequently reported benefits of dimethyl sulfoxide. Patients and users report significant relief from both acute and chronic pain. This includes a wide range of conditions, from headaches and sports injuries to deeper joint and muscle pain. DMSO works through different mechanisms such as reducing inflammatory substances and blocking pain signals, making it a promising alternative to conventional painkillers. DMSO is a particularly interesting option for people who want to avoid conventional painkillers due to intolerances or side effects.
A study investigated the ability of DMSO to soothe nerve injuries. Nerve injuries can easily occur, even from everyday accidents such as twisting a foot, and often the treatment of such injuries is complicated. The results of this study show that the application of DMSO supports the healing of nerves. Improvements were observed at the macroscopic level as well as in nerve function and clinical symptoms.
Inflammation plays an important role in many clinical pictures and is often the actual cause of persistent pain. The anti-inflammatory properties of DMSO are therefore of particular interest. By inhibiting the release of certain pro-inflammatory substances in the body, DMSO can relieve the redness, heat, swelling and pain commonly associated with inflammation. This makes DMSO particularly suitable for inflammatory conditions such as arthritis, but also for inflammation-related skin conditions.
In a study with mice, which served as a model for rheumatoid arthritis, it was shown that dipping the paws in a 70% DMSO solution twice a day reduced the swelling. In addition, the clinical findings of the DMSO-treated mice improved, suggesting a general alleviation of arthritis symptoms.
Minor skin injuries such as cuts, scratches or burns can benefit from the application of DMSO. As DMSO is able to penetrate the skin barrier, scientists believe that it supports the healing process by keeping the skin supple and promoting the transport of nutrients into the injured tissue. This can support the body's natural healing process and accelerate tissue regeneration. DMSO can also help to improve the appearance of scars by promoting skin elasticity and supporting healthy tissue healing.
Another valuable effect of DMSO is that it can enhance the effect of other active ingredients. As a carrier, DMSO can help to deliver other active ingredients through the skin barrier so that they can be active where they are needed most. This "smuggling" can increase the absorption and efficacy of other therapeutic substances, making DMSO a valuable ingredient in the formulation of topical preparations. Thus, combining DMSO with plant extracts or other active ingredients can increase their effectiveness and improve treatment outcomes.
Thoroughly clean the area where DMSO is to be applied with soap and water to remove dirt and other substances. DMSO can transport other substances through the skin, so it is important that the skin is clean to prevent the penetration of unwanted substances.
Apply a small amount of DMSO directly to the affected area. This can be done with fingertips, a clean cloth or a sponge. Preferably gloves should be worn or a clean applicator used to avoid direct contact with the fingers.
Especially when using DMSO for the first time, start with a small amount to observe the skin's reaction. It can be applied 1-2 times a day depending on requirements and tolerance.
After application, allow DMSO to be completely absorbed into the skin. Avoid contact with clothing or materials that may come into contact with the treated area for approximately 30 minutes after application to prevent a reaction or absorption through the material. Observe the skin for signs of reaction such as redness, burning or itching. If any adverse reactions occur, discontinue use.
Despite the therapeutic properties of DMSO (dimethyl sulfoxide), side effects can occur with its external application. Possible side effects are
Instructions for use DMSO drops:
Not approved for internal use.
Composition DMSO drops:
100 % dimethyl sulfoxide (DMSO) of the highest pharmaceutical quality (99.9 % purity)
Sources (in English):
Elisia, I., Nakamura, H., Lam, V., Hofs, E., Cederberg, R., Cait, J., Hughes, M. R., Lee, L., Jia, W., Adomat, H. H., Guns, E. S., McNagny, K. M., Samudio, I., & Krystal, G. (2016). DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PloS one, 11(3), e0152538. doi: 10.1371/journal.pone.0152538
Karim, M., Boikess, R. S., Schwartz, R. A., & Cohen, P. J. (2023). Dimethyl sulfoxide (DMSO): a solvent that may solve selected cutaneous clinical challenges. Archives of dermatological research, 315(6), 1465–1472. doi: 10.1007/s00403-022-02494-1
Jacob, S. W., & Herschler, R. (1986). Pharmacology of DMSO. Cryobiology, 23(1), 14–27. doi: 10.1016/0011-2240(86)90014-3
Gkiatas, I., & Gelalis, I. D. (2021). Dimethylsulfoxide (DMSO) in Peripheral Nerve Regeneration. Journal of investigative surgery : the official journal of the Academy of Surgical Research, 34(4), 466. doi: 10.1080/08941939.2019.1650314
Anzelc, M., & Burkhart, C. G. (2021). DMSO: an aid to combat pain and pruritus. Dermatology online journal, 27(11), 10.5070/D3271156086. https://doi.org/10.5070/D3271156086
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