Bestseller


R-alpha lipoic acid - patented R-form - 21x stronger - laboratory tested
100% vegan stabilized R-form!
- Improves insulin sensitivity in diabetes and lowers blood pressure
- Acts as a powerful antioxidant that protects cells by scavenging free radicals
- Promotes optimal blood supply in polyneuropathy and thus effectively alleviates its symptoms
100% vegan stabilized R-form!
- Improves insulin sensitivity in diabetes and lowers blood pressure
- Acts as a powerful antioxidant that protects cells by scavenging free radicals
- Promotes optimal blood supply in polyneuropathy and thus effectively alleviates its symptoms
Description / R-alpha lipoic acid - patented R-form - 21x stronger - laboratory tested
High-dose R-alpha lipoic acid effectively protects the cells against free radicals
Alpha lipoic acid is a powerful powerful antioxidant that effectively protects your cells from free radicals and can thus prevent serious diseases.
ALA as efficient cell protection!
Researchers agree on this: Alpha lipoic acid, or ALA, as the active ingredient is also called, is one of the most powerful antioxidants, i.e. substances that can effectively combat aggressive and harmful free radicals. Alpha lipoic acid has the ability to protect the entire protect the entire body from disease.
The most effective here is the 100 % pure, stabilized R-form which we offer you at Herbano. Compared to conventional lipoic acid preparations with synthetic S-alpha lipoic acid, the stabilized form is 21 times more bioavailable and therefore significantly more effective.
What exactly is the special effect of R-alpha lipoic acid?
- R-alpha lipoic acid is not only a powerful antioxidant itself, but also ensures that other antioxidants such as vitamin C and vitamin E can be better utilized by the body . This increases the efficiency of these substances enormously, and they can act even better against harmful compounds in the body. In the end, this simply means having improved protection against cell damage!
- Alpha lipoic acid is also a high-quality and powerful energizerthat supplies our cells with new strength.
- Thanks to R-alpha lipoic acid, you can also improve your blood sugar and cholesterol levels under control again.
- Nerve pain in polyneuropathy are sustainably reduced by taking ALA.
- And you keep your brain on its toes by neurodegenerative diseases such as dementia through the power of alpha lipoic acid.
Contents
- Which alpha lipoic acid will give you the best results?
- 6 areas of application in which R-alpha lipoic acid can unfold its special effects
- 1. can R-alpha lipoic acid help with metabolic syndrome and diabetes?
- 2. how can R-alpha lipoic acid help in the treatment of polyneuropathy?
- 3. how R-alpha lipoic acid protects the nervous system from diseases
- 4. the antioxidant effect of R-alpha lipoic acid
- 5 How can alpha lipoic acid support detoxification?
- 6 Can R-alpha lipoic acid really help you lose weight?
- Can side effects occur when taking alpha lipoic acid?
Which alpha lipoic acid is most effective?
When buying alpha lipoic acid, it is particularly important to pay attention to qualitative differences. The main distinction here is between
- R-alpha lipoic acid
- S-alpha lipoic acid
Most of the food supplements available consist only to a small extent of the biologically active R-form and for the most part the ineffective S-form.
Only the 100 % pure R-alpha lipoic acid is effective, as it is an endogenous form with extremely high bioavailability. bioavailability.
S-alpha lipoic acid, on the other hand, is a synthetic form with a barely noticeable degree of effectiveness. Herbano therefore exclusively uses 100 % pure stabilized R-alpha lipoic acid.
6 areas of application in which R-alpha lipoic acid can unfold its special effects for your health
1. can R-alpha lipoic acid help with metabolic syndrome and diabetes?
Alpha lipoic acid supports the processing of the sugar molecule glucose in the body. If glucose can be broken down more quickly as a result, this naturally influences the blood sugar level: the blood sugar drops because the sugar in the blood decreases.
Also with regard to insulin sensitivity and important key factors of cardiovascular health lipoic acid also plays an important role. This is because R-alpha lipoic acid lowers blood pressure and increases the body's response to insulin, resulting in a decrease in blood sugar levels.
In this regard, a review of experimental studies showed that R-alpha lipoic acid can be effective in attenuating several risk factors of metabolic syndrome, which is often the trigger for type 2 diabetes. trigger for type 2 diabetes.
According to this, alpha lipoic acid not only reduces blood pressure and the insulin resistance, but also improves the lipid profile and contributes to weight reduction contributes to weight reduction. Science is increasingly recognizing the potential of ALA as a therapeutic agent for patients with metabolic syndrome.
Can R-alpha lipoic acid also help if you are already suffering from symptoms?
Even if complications associated with diabetes have already occurred, alpha lipoic acid can help. For example, it has proven effective in the treatment of diabetic neuropathy has proven to be very effective. This is a nerve disorder caused by diabetes due to the toxic effect of high glucose levels on the nervous system. Typical symptoms of diabetic neuropathy are numbness, tingling and a painful, burning sensation in the extremities.
Research has shown that the administration of ALA leads to a significant improvement in symptoms. The oral intake of R-alpha lipoic acid for 5 weeks was able to significantly reduce the symptoms of diabetic neuropathy. Doses of between 600 and 1,800 mg per day taken orally proved to be particularly effective.

2. how can R-alpha lipoic acid help in the treatment of polyneuropathy?
With regard to the effect of alpha-lipoic acid on the nerves, it can be concluded that its antioxidant properties have a significant supportive effect in diabetic polyneuropathy and can effectively relieve nerve pain.
Polyneuropathy is a painful nerve disease that is one of the most common complications of diabetes. It occurs in over 60 % of diabetics. The use of alpha lipoic acid in high doses is already recognized throughout Germany for the treatment of typical symptoms such as tingling, stinging, burning or sluggishness in the toes.
In this context, alpha lipoic acid ensures that the blood supply is maintained by preventing the formation of harmful free radicals, which occur due to the excessive sugar content in the blood and damage the nerves.
This enables the body effectively and sustainably from oxidative stress. oxidative stress. And overall, symptoms such as pain, burning, numbness and tingling are noticeably reduced and the blood supply to the nerves is effectively improved.
3. how R-alpha lipoic acid protects the nervous system from diseases
The special effect of alpha-lipoic acid on the brain enables it to penetrate all the components of the nerve cells.
In this context, new evidence suggests that alpha lipoic acid is effective in protection against one of the most feared diseases of old age - Alzheimer's disease. Researchers have identified a number of mechanisms by which ALA can help to prevent or at least alleviate Alzheimer's disease. This is because alpha lipoic acid produces the important neurotransmitter acetylcholine, which is not sufficiently present in the brains of Alzheimer's patients.
Furthermore, initial scientific results indicate that the effect of alpha-lipoic acid in the brain could also be beneficial in multiple sclerosis. Studies have shown that the administration of alpha-lipoic acid can effectively reduce the inflammatory symptoms associated with this disease. This is supported by numerous animal studies.
4. the antioxidant effect of R-alpha lipoic acid
R-alpha lipoic acid is one of the strongest antioxidants and can therefore protect cells from premature ageing by scavenging free radicals.
At the same time, the acid also reactivates other antioxidants such as vitamins C and E and coenzyme Q10, which regain their full strength and effectiveness.
And the production of glutathione is also promoted by R-alpha lipoic acid. The older we get, the more the supply of glutathione in our body decreases. However, glutathione is essential for healthy eyes (lens & retina) and radiant, firm skin. The powerful antioxidant also has the ability to break down toxic substances from the liver, such as heavy metals, and regenerate the liver.
Even in terms of hair growth , there are some studies and reports suggesting that alpha lipoic acid could reduce hair loss and promote hair growth.
It is assumed that the antioxidant effect of alpha-lipoic acid reduces oxidative stress, which can play a role in hair loss, as a possible mechanism. Oxidative stress can damage the hair follicles and thus impair hair growth. In addition, alpha-lipoic acid could promote blood circulation in the scalp and thus improve the supply of nutrients to the hair follicles.
All these factors are essential components in the fight against age and disease.
5 How can alpha lipoic acid support detoxification?
The universal antioxidant R-alpha lipoic acid may also protect the body from toxic (heavy) metals. Heavy metal poisoning can be caused by environmental influences or food intake. However, the acid has the ability to bind dangerous substances such as arsenic, cadmium, lead or mercury and thus effectively prevent their activation. In this way, it helps to protect the sensitive nervous system from the negative and dangerous effects of poisoning.
6 Can R-alpha lipoic acid really help you lose weight?
According to a study from 2020, R-alpha lipoic acid can even support weight loss. The participants who took R-alpha lipoic acid for six months lost a significant amount of weight compared to the placebo group - without having changed anything about their diet or exercise habits. On average, the test subjects lost 1 kg of pure body fat or 1.7 % of their body weight. This effect is due to the fact that alpha lipoic acid has the ability to reduce sugar.
Can side effects occur when taking alpha lipoic acid?
Alpha lipoic acid is considered to be very well tolerated. Therefore, when adhering to the recommended dosages according to the Physicians' Desk Reference (PDR) there are no known side effects and no reports of overdoses.
However, there is evidence to suggest that high doses of alpha lipoic acid can contribute to an undersupply of thiamine. The side effects that occur here are allergic reactions such as hives, headaches, muscle cramps or skin rashes.
Recommended intake R-alpha lipoic acid:
- As a dietary supplement, take up to 3 capsules a day with plenty of water, preferably half an hour before meals.
- Dairy products should be avoided with these meals so as not to weaken the effectiveness of R-alpha lipoic acid.
Do not exceed the recommended daily intake.
Food supplements are not a substitute for a balanced and varied diet.
Store in a cool, dry place away from light. Keep out of the reach of small children.
Composition R-alpha lipoic acid:
R-alpha lipoic acid, hydroxypropyl methylcellulose (capsule shell)
Quantities per capsule:
R-alpha lipoic acid |
400 mg |

glutenfrei

laktosefrei

ohnegelatin

vegan
Is it the stabilized form of R-alpha lipoic acid?
Yes, it is the body-identical and stabilized form of R-alpha lipoic acid.
Is your product the pure R-form, or does it also contain the S-form of alpha lipoic acid?
Herbano uses only 100% pure R-alpha lipoic acid.
How quickly do alpha lipoic acid capsules work?
As alpha lipoic acid is both fat and water soluble, it can be optimally absorbed in the gastrointestinal tract. It is therefore distributed directly throughout the entire organism.
Is R-alpha lipoic acid soluble in water?
Yes, it is both water- and fat-soluble.
Does R-Alpha Lipoic Acid Capsules contain magnesium stearate?
No, our stabilized form of R-alpha lipoic acid no longer contains magnesium stearate.
Can alpha lipoic acid be taken with milk or dairy products?
No, R-alpha lipoic acid should not be taken with dairy products. The reason for this is that the medium-chain fatty acids contained in dairy products make the absorption of R-alpha lipoic acid more difficult.
To ensure the highest possible bioavailability, R-alpha lipoic acid should not be taken later than half an hour before a meal to be on the safe side.
Important: Iron and magnesium supplements as well as milk (high calcium content) should not be taken together with alpha-lipoic acid, as the active ingredient likes to form compounds with metals (so-called metal chelator) and the effect can be weakened as a result.
Should alpha lipoic acid be taken with meals?
As many meals contain dairy products, which inhibit the bioavailability of alpha lipoic acid, we recommend not taking the product with meals to be on the safe side.
Sources (in English):
Ziegler, D., Low, P. A., Freeman, R., Tritschler, H. & Vinik, A. I. (2016, March). Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial. Journal of diabetes and its complications, 30(2):350-6. doi: 10.1016/j.jdiacomp.2015.10.018
Garcia-Alcala, H., Santos Vichido, C. I., Islas Macedo, S., Genestier-Tamborero, C. N., Minutti-Palacios, M. Hirales Tames, O. et al. (2015). Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading, Journal of diabetes research, 2015:189857. doi: 10.1155/2015/189857
Dy, S. M., Bennett, W. L., Sharma, R., Zhang, A., Waldfogel, J. M., Nesbit, S. A. et al. (2017, March) Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); Report No.: 17-EHC005-EF
Várkonyi, T., Körei, A., Putz, Z., Martos, T., Keresztes, K., Lengyel, C. et al. (2017, October) Advances in the management of diabetic neuropathy, Minerva Medica, 108(5):419-437. doi: 10.23736/S0026-4806.17.05257-0
Scaramuzza, A., Giani, E., Redaelli, F., Ungheri, S., Macedoni, M., Giudici, V. et al. (2015) Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial, Journal of diabetes research, 2015:474561. doi: 10.1155/2015/474561
Packer, L., Witt, E. H. & Tritschler, H. J. (1995, August). alpha-Lipoic acid as a biological antioxidant. Free Radical Biology & Medicine, 19(2):227-50
Evans, J. L. & Goldfine, I. D. (2000). Alpha-lipoic acid: a multifunctional antioxidant that improves [von Google zensierter Begriff] sensitivity in patients with type 2 diabetes. Diabetes Technology & Therapeutics, 2(3):401-13, doi: 10.1089/15209150050194279
Desideri I., Francolini G., Becherini C., Terziani F., Delli Paoli C., Olmetto E. et al. (2017, March). Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera®) for chemotherapy-induced peripheral neuropathy management, a prospective study. Med Oncol, 34(3):46, doi: 10.1007/s12032-017-0907-4
Zhang X., Zhang Y., Gao X., Wu J., Jiao X., Zhao J. et al. (2014, May). Investigating the role of backward walking therapy in alleviating plantar pressure of patients with diabetic peripheral neuropathy. Arch Phys Med Rehabil, 95(5):832-9, doi: 10.1016/j.apmr.2014.01.003
Guo Y., Jones D., Palmer J. L., Forman A., Dakhil S. R., Velasco M. R. et al. (2014, May). Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. Support Care Cancer, 22(5):1223-31, doi: 10.1007/s00520-013-2075-1
Jo S. H., Kim S. A., Kim H. S., Han S. J., Park W. J. & Choi Y. J. (2013). Alpha-lipoic acid for the prevention of contrast-induced nephropathy in patients undergoing coronary angiography: the ALIVE study - a prospective randomized trial. Cardiology, 126(3):159-66, doi: 10.1159/000353812
Pop-Busui R., Stevens M. J., Raffel D. M., White E. A., Mehta M., Plunkett C. D. et al. (2013, August). Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in type 1 diabetes: a randomised controlled trial. Diabetologia, 56(8):1835-44, doi: 10.1007/s00125-013-2942-9
Ibrahimpasic K. (2013). Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arch, 67(1):7-9.
Bertolotto F. & Massone A. (2012, March). Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. Drugs R. D, 12(1):29-34, doi: 10.2165/11599200-000000000-00000
Ziegler D., Low P. A., Litchy W. J., Boulton A. J., Vinik A. I., Freeman R. et al. (2011, September). Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care, 34(9):2054-60, doi: 10.2337/dc11-0503
Sadykova H. G. & Nazhmutdinova D. K. (2009, January-February). [Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with diabetic autonomic neuropathy]. Lik Sprava, (1-2):22-8.
Statsenko M. E., Poletaeva L. V., Turkina S. V., Apukhtin A. F. & Dudchenko G. P. (2008). [Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy]. Ter Arkh, 80(10):27-30.
Volchegorskii I. A., Alekseev M. N., Volchegorskaia M. I. & Rassokhina L. M. (2008). [Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome]. Klin Med (Mosk), 86(10):52-9
Huang E. A. & Gitelman S. E. (2008, June). The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. Pediatr Diabetes, 9(3 Pt 2):69-73, doi: 10.1111/j.1399-5448.2007.00342.x
Liu F., Zhang Y., Yang M., Liu B. Shen Y. D., Jia W. P. et al. (2007, October). [Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study]. Zhonghua Yi Xue Za Zhi, 87(38):2706-9.
Magis D., Ambrosini A., Sándor P., Jacquy J., Laloux P. & Schoenen J. (2007, January). A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache, 47(1):52-7, doi: 10.1111/j.1526-4610.2006.00626.x
Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A. et al. (2006, November). Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care, 29(11):2365-70, doi: 10.2337/dc06-1216
Negrisanu G., Rosu M., Bolte B., Lefter D. & Diabelea D. (1999, July-September). Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy. Rom J Intern Med, 37(3):297-306
Tankova T., Koev D. & Dakovska L. (2004). Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). Rom J Intern Med, 42(2):457-64
Jedynasty K., Łomińska T., Toruńska K. & Kasperska-Czyzykowa T. (2003, August). [Acute painful neuropathy at the initial period of effective insulin therapy]. Pol Arch Med Wewn, 110(2):885-90
Femiano F., Scully C. & Gombros F. (2002, December). Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy. Int J Oral Maxillofac Surg, 31(6):625-8, doi: 10.1054/ijom.2002.0276
Haak E., Usadel K. H., Kusterer K., Amini P., Frommeyer R., Tritschler H. J. et al. (2000). Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. Exp Clin Endocrinol Diabetes, 108(3):168-74, doi: 10.1055/s-2000-7739
Androne L., Gavan N. A., Veresiu I. A. & Orasan R. (2000, March-April). In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo, 14(2):327-30
Ziegler D. & Gries F. A. (1997, September). Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes, 46 Suppl 2:S62-6.
Description / R-alpha lipoic acid - patented R-form - 21x stronger - laboratory tested
High-dose R-alpha lipoic acid effectively protects the cells against free radicals
Alpha lipoic acid is a powerful powerful antioxidant that effectively protects your cells from free radicals and can thus prevent serious diseases.
ALA as efficient cell protection!
Researchers agree on this: Alpha lipoic acid, or ALA, as the active ingredient is also called, is one of the most powerful antioxidants, i.e. substances that can effectively combat aggressive and harmful free radicals. Alpha lipoic acid has the ability to protect the entire protect the entire body from disease.
The most effective here is the 100 % pure, stabilized R-form which we offer you at Herbano. Compared to conventional lipoic acid preparations with synthetic S-alpha lipoic acid, the stabilized form is 21 times more bioavailable and therefore significantly more effective.
What exactly is the special effect of R-alpha lipoic acid?
- R-alpha lipoic acid is not only a powerful antioxidant itself, but also ensures that other antioxidants such as vitamin C and vitamin E can be better utilized by the body . This increases the efficiency of these substances enormously, and they can act even better against harmful compounds in the body. In the end, this simply means having improved protection against cell damage!
- Alpha lipoic acid is also a high-quality and powerful energizerthat supplies our cells with new strength.
- Thanks to R-alpha lipoic acid, you can also improve your blood sugar and cholesterol levels under control again.
- Nerve pain in polyneuropathy are sustainably reduced by taking ALA.
- And you keep your brain on its toes by neurodegenerative diseases such as dementia through the power of alpha lipoic acid.
Contents
- Which alpha lipoic acid will give you the best results?
- 6 areas of application in which R-alpha lipoic acid can unfold its special effects
- 1. can R-alpha lipoic acid help with metabolic syndrome and diabetes?
- 2. how can R-alpha lipoic acid help in the treatment of polyneuropathy?
- 3. how R-alpha lipoic acid protects the nervous system from diseases
- 4. the antioxidant effect of R-alpha lipoic acid
- 5 How can alpha lipoic acid support detoxification?
- 6 Can R-alpha lipoic acid really help you lose weight?
- Can side effects occur when taking alpha lipoic acid?
Which alpha lipoic acid is most effective?
When buying alpha lipoic acid, it is particularly important to pay attention to qualitative differences. The main distinction here is between
- R-alpha lipoic acid
- S-alpha lipoic acid
Most of the food supplements available consist only to a small extent of the biologically active R-form and for the most part the ineffective S-form.
Only the 100 % pure R-alpha lipoic acid is effective, as it is an endogenous form with extremely high bioavailability. bioavailability.
S-alpha lipoic acid, on the other hand, is a synthetic form with a barely noticeable degree of effectiveness. Herbano therefore exclusively uses 100 % pure stabilized R-alpha lipoic acid.
6 areas of application in which R-alpha lipoic acid can unfold its special effects for your health
1. can R-alpha lipoic acid help with metabolic syndrome and diabetes?
Alpha lipoic acid supports the processing of the sugar molecule glucose in the body. If glucose can be broken down more quickly as a result, this naturally influences the blood sugar level: the blood sugar drops because the sugar in the blood decreases.
Also with regard to insulin sensitivity and important key factors of cardiovascular health lipoic acid also plays an important role. This is because R-alpha lipoic acid lowers blood pressure and increases the body's response to insulin, resulting in a decrease in blood sugar levels.
In this regard, a review of experimental studies showed that R-alpha lipoic acid can be effective in attenuating several risk factors of metabolic syndrome, which is often the trigger for type 2 diabetes. trigger for type 2 diabetes.
According to this, alpha lipoic acid not only reduces blood pressure and the insulin resistance, but also improves the lipid profile and contributes to weight reduction contributes to weight reduction. Science is increasingly recognizing the potential of ALA as a therapeutic agent for patients with metabolic syndrome.
Can R-alpha lipoic acid also help if you are already suffering from symptoms?
Even if complications associated with diabetes have already occurred, alpha lipoic acid can help. For example, it has proven effective in the treatment of diabetic neuropathy has proven to be very effective. This is a nerve disorder caused by diabetes due to the toxic effect of high glucose levels on the nervous system. Typical symptoms of diabetic neuropathy are numbness, tingling and a painful, burning sensation in the extremities.
Research has shown that the administration of ALA leads to a significant improvement in symptoms. The oral intake of R-alpha lipoic acid for 5 weeks was able to significantly reduce the symptoms of diabetic neuropathy. Doses of between 600 and 1,800 mg per day taken orally proved to be particularly effective.

2. how can R-alpha lipoic acid help in the treatment of polyneuropathy?
With regard to the effect of alpha-lipoic acid on the nerves, it can be concluded that its antioxidant properties have a significant supportive effect in diabetic polyneuropathy and can effectively relieve nerve pain.
Polyneuropathy is a painful nerve disease that is one of the most common complications of diabetes. It occurs in over 60 % of diabetics. The use of alpha lipoic acid in high doses is already recognized throughout Germany for the treatment of typical symptoms such as tingling, stinging, burning or sluggishness in the toes.
In this context, alpha lipoic acid ensures that the blood supply is maintained by preventing the formation of harmful free radicals, which occur due to the excessive sugar content in the blood and damage the nerves.
This enables the body effectively and sustainably from oxidative stress. oxidative stress. And overall, symptoms such as pain, burning, numbness and tingling are noticeably reduced and the blood supply to the nerves is effectively improved.
3. how R-alpha lipoic acid protects the nervous system from diseases
The special effect of alpha-lipoic acid on the brain enables it to penetrate all the components of the nerve cells.
In this context, new evidence suggests that alpha lipoic acid is effective in protection against one of the most feared diseases of old age - Alzheimer's disease. Researchers have identified a number of mechanisms by which ALA can help to prevent or at least alleviate Alzheimer's disease. This is because alpha lipoic acid produces the important neurotransmitter acetylcholine, which is not sufficiently present in the brains of Alzheimer's patients.
Furthermore, initial scientific results indicate that the effect of alpha-lipoic acid in the brain could also be beneficial in multiple sclerosis. Studies have shown that the administration of alpha-lipoic acid can effectively reduce the inflammatory symptoms associated with this disease. This is supported by numerous animal studies.
4. the antioxidant effect of R-alpha lipoic acid
R-alpha lipoic acid is one of the strongest antioxidants and can therefore protect cells from premature ageing by scavenging free radicals.
At the same time, the acid also reactivates other antioxidants such as vitamins C and E and coenzyme Q10, which regain their full strength and effectiveness.
And the production of glutathione is also promoted by R-alpha lipoic acid. The older we get, the more the supply of glutathione in our body decreases. However, glutathione is essential for healthy eyes (lens & retina) and radiant, firm skin. The powerful antioxidant also has the ability to break down toxic substances from the liver, such as heavy metals, and regenerate the liver.
Even in terms of hair growth , there are some studies and reports suggesting that alpha lipoic acid could reduce hair loss and promote hair growth.
It is assumed that the antioxidant effect of alpha-lipoic acid reduces oxidative stress, which can play a role in hair loss, as a possible mechanism. Oxidative stress can damage the hair follicles and thus impair hair growth. In addition, alpha-lipoic acid could promote blood circulation in the scalp and thus improve the supply of nutrients to the hair follicles.
All these factors are essential components in the fight against age and disease.
5 How can alpha lipoic acid support detoxification?
The universal antioxidant R-alpha lipoic acid may also protect the body from toxic (heavy) metals. Heavy metal poisoning can be caused by environmental influences or food intake. However, the acid has the ability to bind dangerous substances such as arsenic, cadmium, lead or mercury and thus effectively prevent their activation. In this way, it helps to protect the sensitive nervous system from the negative and dangerous effects of poisoning.
6 Can R-alpha lipoic acid really help you lose weight?
According to a study from 2020, R-alpha lipoic acid can even support weight loss. The participants who took R-alpha lipoic acid for six months lost a significant amount of weight compared to the placebo group - without having changed anything about their diet or exercise habits. On average, the test subjects lost 1 kg of pure body fat or 1.7 % of their body weight. This effect is due to the fact that alpha lipoic acid has the ability to reduce sugar.
Can side effects occur when taking alpha lipoic acid?
Alpha lipoic acid is considered to be very well tolerated. Therefore, when adhering to the recommended dosages according to the Physicians' Desk Reference (PDR) there are no known side effects and no reports of overdoses.
However, there is evidence to suggest that high doses of alpha lipoic acid can contribute to an undersupply of thiamine. The side effects that occur here are allergic reactions such as hives, headaches, muscle cramps or skin rashes.
Recommended intake R-alpha lipoic acid:
- As a dietary supplement, take up to 3 capsules a day with plenty of water, preferably half an hour before meals.
- Dairy products should be avoided with these meals so as not to weaken the effectiveness of R-alpha lipoic acid.
Do not exceed the recommended daily intake.
Food supplements are not a substitute for a balanced and varied diet.
Store in a cool, dry place away from light. Keep out of the reach of small children.
Composition R-alpha lipoic acid:
R-alpha lipoic acid, hydroxypropyl methylcellulose (capsule shell)
Quantities per capsule:
R-alpha lipoic acid |
400 mg |

glutenfrei

laktosefrei

ohnegelatin

vegan
Is it the stabilized form of R-alpha lipoic acid?
Yes, it is the body-identical and stabilized form of R-alpha lipoic acid.
Is your product the pure R-form, or does it also contain the S-form of alpha lipoic acid?
Herbano uses only 100% pure R-alpha lipoic acid.
How quickly do alpha lipoic acid capsules work?
As alpha lipoic acid is both fat and water soluble, it can be optimally absorbed in the gastrointestinal tract. It is therefore distributed directly throughout the entire organism.
Is R-alpha lipoic acid soluble in water?
Yes, it is both water- and fat-soluble.
Does R-Alpha Lipoic Acid Capsules contain magnesium stearate?
No, our stabilized form of R-alpha lipoic acid no longer contains magnesium stearate.
Can alpha lipoic acid be taken with milk or dairy products?
No, R-alpha lipoic acid should not be taken with dairy products. The reason for this is that the medium-chain fatty acids contained in dairy products make the absorption of R-alpha lipoic acid more difficult.
To ensure the highest possible bioavailability, R-alpha lipoic acid should not be taken later than half an hour before a meal to be on the safe side.
Important: Iron and magnesium supplements as well as milk (high calcium content) should not be taken together with alpha-lipoic acid, as the active ingredient likes to form compounds with metals (so-called metal chelator) and the effect can be weakened as a result.
Should alpha lipoic acid be taken with meals?
As many meals contain dairy products, which inhibit the bioavailability of alpha lipoic acid, we recommend not taking the product with meals to be on the safe side.
Sources (in English):
Ziegler, D., Low, P. A., Freeman, R., Tritschler, H. & Vinik, A. I. (2016, March). Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial. Journal of diabetes and its complications, 30(2):350-6. doi: 10.1016/j.jdiacomp.2015.10.018
Garcia-Alcala, H., Santos Vichido, C. I., Islas Macedo, S., Genestier-Tamborero, C. N., Minutti-Palacios, M. Hirales Tames, O. et al. (2015). Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading, Journal of diabetes research, 2015:189857. doi: 10.1155/2015/189857
Dy, S. M., Bennett, W. L., Sharma, R., Zhang, A., Waldfogel, J. M., Nesbit, S. A. et al. (2017, March) Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); Report No.: 17-EHC005-EF
Várkonyi, T., Körei, A., Putz, Z., Martos, T., Keresztes, K., Lengyel, C. et al. (2017, October) Advances in the management of diabetic neuropathy, Minerva Medica, 108(5):419-437. doi: 10.23736/S0026-4806.17.05257-0
Scaramuzza, A., Giani, E., Redaelli, F., Ungheri, S., Macedoni, M., Giudici, V. et al. (2015) Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial, Journal of diabetes research, 2015:474561. doi: 10.1155/2015/474561
Packer, L., Witt, E. H. & Tritschler, H. J. (1995, August). alpha-Lipoic acid as a biological antioxidant. Free Radical Biology & Medicine, 19(2):227-50
Evans, J. L. & Goldfine, I. D. (2000). Alpha-lipoic acid: a multifunctional antioxidant that improves [von Google zensierter Begriff] sensitivity in patients with type 2 diabetes. Diabetes Technology & Therapeutics, 2(3):401-13, doi: 10.1089/15209150050194279
Desideri I., Francolini G., Becherini C., Terziani F., Delli Paoli C., Olmetto E. et al. (2017, March). Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera®) for chemotherapy-induced peripheral neuropathy management, a prospective study. Med Oncol, 34(3):46, doi: 10.1007/s12032-017-0907-4
Zhang X., Zhang Y., Gao X., Wu J., Jiao X., Zhao J. et al. (2014, May). Investigating the role of backward walking therapy in alleviating plantar pressure of patients with diabetic peripheral neuropathy. Arch Phys Med Rehabil, 95(5):832-9, doi: 10.1016/j.apmr.2014.01.003
Guo Y., Jones D., Palmer J. L., Forman A., Dakhil S. R., Velasco M. R. et al. (2014, May). Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. Support Care Cancer, 22(5):1223-31, doi: 10.1007/s00520-013-2075-1
Jo S. H., Kim S. A., Kim H. S., Han S. J., Park W. J. & Choi Y. J. (2013). Alpha-lipoic acid for the prevention of contrast-induced nephropathy in patients undergoing coronary angiography: the ALIVE study - a prospective randomized trial. Cardiology, 126(3):159-66, doi: 10.1159/000353812
Pop-Busui R., Stevens M. J., Raffel D. M., White E. A., Mehta M., Plunkett C. D. et al. (2013, August). Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in type 1 diabetes: a randomised controlled trial. Diabetologia, 56(8):1835-44, doi: 10.1007/s00125-013-2942-9
Ibrahimpasic K. (2013). Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arch, 67(1):7-9.
Bertolotto F. & Massone A. (2012, March). Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. Drugs R. D, 12(1):29-34, doi: 10.2165/11599200-000000000-00000
Ziegler D., Low P. A., Litchy W. J., Boulton A. J., Vinik A. I., Freeman R. et al. (2011, September). Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care, 34(9):2054-60, doi: 10.2337/dc11-0503
Sadykova H. G. & Nazhmutdinova D. K. (2009, January-February). [Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with diabetic autonomic neuropathy]. Lik Sprava, (1-2):22-8.
Statsenko M. E., Poletaeva L. V., Turkina S. V., Apukhtin A. F. & Dudchenko G. P. (2008). [Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy]. Ter Arkh, 80(10):27-30.
Volchegorskii I. A., Alekseev M. N., Volchegorskaia M. I. & Rassokhina L. M. (2008). [Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome]. Klin Med (Mosk), 86(10):52-9
Huang E. A. & Gitelman S. E. (2008, June). The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. Pediatr Diabetes, 9(3 Pt 2):69-73, doi: 10.1111/j.1399-5448.2007.00342.x
Liu F., Zhang Y., Yang M., Liu B. Shen Y. D., Jia W. P. et al. (2007, October). [Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study]. Zhonghua Yi Xue Za Zhi, 87(38):2706-9.
Magis D., Ambrosini A., Sándor P., Jacquy J., Laloux P. & Schoenen J. (2007, January). A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache, 47(1):52-7, doi: 10.1111/j.1526-4610.2006.00626.x
Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A. et al. (2006, November). Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care, 29(11):2365-70, doi: 10.2337/dc06-1216
Negrisanu G., Rosu M., Bolte B., Lefter D. & Diabelea D. (1999, July-September). Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy. Rom J Intern Med, 37(3):297-306
Tankova T., Koev D. & Dakovska L. (2004). Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). Rom J Intern Med, 42(2):457-64
Jedynasty K., Łomińska T., Toruńska K. & Kasperska-Czyzykowa T. (2003, August). [Acute painful neuropathy at the initial period of effective insulin therapy]. Pol Arch Med Wewn, 110(2):885-90
Femiano F., Scully C. & Gombros F. (2002, December). Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy. Int J Oral Maxillofac Surg, 31(6):625-8, doi: 10.1054/ijom.2002.0276
Haak E., Usadel K. H., Kusterer K., Amini P., Frommeyer R., Tritschler H. J. et al. (2000). Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. Exp Clin Endocrinol Diabetes, 108(3):168-74, doi: 10.1055/s-2000-7739
Androne L., Gavan N. A., Veresiu I. A. & Orasan R. (2000, March-April). In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo, 14(2):327-30
Ziegler D. & Gries F. A. (1997, September). Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes, 46 Suppl 2:S62-6.
Description / R-alpha lipoic acid - patented R-form - 21x stronger - laboratory tested
High-dose R-alpha lipoic acid effectively protects the cells against free radicals
Alpha lipoic acid is a powerful powerful antioxidant that effectively protects your cells from free radicals and can thus prevent serious diseases.
ALA as efficient cell protection!
Researchers agree on this: Alpha lipoic acid, or ALA, as the active ingredient is also called, is one of the most powerful antioxidants, i.e. substances that can effectively combat aggressive and harmful free radicals. Alpha lipoic acid has the ability to protect the entire protect the entire body from disease.
The most effective here is the 100 % pure, stabilized R-form which we offer you at Herbano. Compared to conventional lipoic acid preparations with synthetic S-alpha lipoic acid, the stabilized form is 21 times more bioavailable and therefore significantly more effective.
What exactly is the special effect of R-alpha lipoic acid?
- R-alpha lipoic acid is not only a powerful antioxidant itself, but also ensures that other antioxidants such as vitamin C and vitamin E can be better utilized by the body . This increases the efficiency of these substances enormously, and they can act even better against harmful compounds in the body. In the end, this simply means having improved protection against cell damage!
- Alpha lipoic acid is also a high-quality and powerful energizerthat supplies our cells with new strength.
- Thanks to R-alpha lipoic acid, you can also improve your blood sugar and cholesterol levels under control again.
- Nerve pain in polyneuropathy are sustainably reduced by taking ALA.
- And you keep your brain on its toes by neurodegenerative diseases such as dementia through the power of alpha lipoic acid.
Contents
- Which alpha lipoic acid will give you the best results?
- 6 areas of application in which R-alpha lipoic acid can unfold its special effects
- 1. can R-alpha lipoic acid help with metabolic syndrome and diabetes?
- 2. how can R-alpha lipoic acid help in the treatment of polyneuropathy?
- 3. how R-alpha lipoic acid protects the nervous system from diseases
- 4. the antioxidant effect of R-alpha lipoic acid
- 5 How can alpha lipoic acid support detoxification?
- 6 Can R-alpha lipoic acid really help you lose weight?
- Can side effects occur when taking alpha lipoic acid?
Which alpha lipoic acid is most effective?
When buying alpha lipoic acid, it is particularly important to pay attention to qualitative differences. The main distinction here is between
- R-alpha lipoic acid
- S-alpha lipoic acid
Most of the food supplements available consist only to a small extent of the biologically active R-form and for the most part the ineffective S-form.
Only the 100 % pure R-alpha lipoic acid is effective, as it is an endogenous form with extremely high bioavailability. bioavailability.
S-alpha lipoic acid, on the other hand, is a synthetic form with a barely noticeable degree of effectiveness. Herbano therefore exclusively uses 100 % pure stabilized R-alpha lipoic acid.
6 areas of application in which R-alpha lipoic acid can unfold its special effects for your health
1. can R-alpha lipoic acid help with metabolic syndrome and diabetes?
Alpha lipoic acid supports the processing of the sugar molecule glucose in the body. If glucose can be broken down more quickly as a result, this naturally influences the blood sugar level: the blood sugar drops because the sugar in the blood decreases.
Also with regard to insulin sensitivity and important key factors of cardiovascular health lipoic acid also plays an important role. This is because R-alpha lipoic acid lowers blood pressure and increases the body's response to insulin, resulting in a decrease in blood sugar levels.
In this regard, a review of experimental studies showed that R-alpha lipoic acid can be effective in attenuating several risk factors of metabolic syndrome, which is often the trigger for type 2 diabetes. trigger for type 2 diabetes.
According to this, alpha lipoic acid not only reduces blood pressure and the insulin resistance, but also improves the lipid profile and contributes to weight reduction contributes to weight reduction. Science is increasingly recognizing the potential of ALA as a therapeutic agent for patients with metabolic syndrome.
Can R-alpha lipoic acid also help if you are already suffering from symptoms?
Even if complications associated with diabetes have already occurred, alpha lipoic acid can help. For example, it has proven effective in the treatment of diabetic neuropathy has proven to be very effective. This is a nerve disorder caused by diabetes due to the toxic effect of high glucose levels on the nervous system. Typical symptoms of diabetic neuropathy are numbness, tingling and a painful, burning sensation in the extremities.
Research has shown that the administration of ALA leads to a significant improvement in symptoms. The oral intake of R-alpha lipoic acid for 5 weeks was able to significantly reduce the symptoms of diabetic neuropathy. Doses of between 600 and 1,800 mg per day taken orally proved to be particularly effective.

2. how can R-alpha lipoic acid help in the treatment of polyneuropathy?
With regard to the effect of alpha-lipoic acid on the nerves, it can be concluded that its antioxidant properties have a significant supportive effect in diabetic polyneuropathy and can effectively relieve nerve pain.
Polyneuropathy is a painful nerve disease that is one of the most common complications of diabetes. It occurs in over 60 % of diabetics. The use of alpha lipoic acid in high doses is already recognized throughout Germany for the treatment of typical symptoms such as tingling, stinging, burning or sluggishness in the toes.
In this context, alpha lipoic acid ensures that the blood supply is maintained by preventing the formation of harmful free radicals, which occur due to the excessive sugar content in the blood and damage the nerves.
This enables the body effectively and sustainably from oxidative stress. oxidative stress. And overall, symptoms such as pain, burning, numbness and tingling are noticeably reduced and the blood supply to the nerves is effectively improved.
3. how R-alpha lipoic acid protects the nervous system from diseases
The special effect of alpha-lipoic acid on the brain enables it to penetrate all the components of the nerve cells.
In this context, new evidence suggests that alpha lipoic acid is effective in protection against one of the most feared diseases of old age - Alzheimer's disease. Researchers have identified a number of mechanisms by which ALA can help to prevent or at least alleviate Alzheimer's disease. This is because alpha lipoic acid produces the important neurotransmitter acetylcholine, which is not sufficiently present in the brains of Alzheimer's patients.
Furthermore, initial scientific results indicate that the effect of alpha-lipoic acid in the brain could also be beneficial in multiple sclerosis. Studies have shown that the administration of alpha-lipoic acid can effectively reduce the inflammatory symptoms associated with this disease. This is supported by numerous animal studies.
4. the antioxidant effect of R-alpha lipoic acid
R-alpha lipoic acid is one of the strongest antioxidants and can therefore protect cells from premature ageing by scavenging free radicals.
At the same time, the acid also reactivates other antioxidants such as vitamins C and E and coenzyme Q10, which regain their full strength and effectiveness.
And the production of glutathione is also promoted by R-alpha lipoic acid. The older we get, the more the supply of glutathione in our body decreases. However, glutathione is essential for healthy eyes (lens & retina) and radiant, firm skin. The powerful antioxidant also has the ability to break down toxic substances from the liver, such as heavy metals, and regenerate the liver.
Even in terms of hair growth , there are some studies and reports suggesting that alpha lipoic acid could reduce hair loss and promote hair growth.
It is assumed that the antioxidant effect of alpha-lipoic acid reduces oxidative stress, which can play a role in hair loss, as a possible mechanism. Oxidative stress can damage the hair follicles and thus impair hair growth. In addition, alpha-lipoic acid could promote blood circulation in the scalp and thus improve the supply of nutrients to the hair follicles.
All these factors are essential components in the fight against age and disease.
5 How can alpha lipoic acid support detoxification?
The universal antioxidant R-alpha lipoic acid may also protect the body from toxic (heavy) metals. Heavy metal poisoning can be caused by environmental influences or food intake. However, the acid has the ability to bind dangerous substances such as arsenic, cadmium, lead or mercury and thus effectively prevent their activation. In this way, it helps to protect the sensitive nervous system from the negative and dangerous effects of poisoning.
6 Can R-alpha lipoic acid really help you lose weight?
According to a study from 2020, R-alpha lipoic acid can even support weight loss. The participants who took R-alpha lipoic acid for six months lost a significant amount of weight compared to the placebo group - without having changed anything about their diet or exercise habits. On average, the test subjects lost 1 kg of pure body fat or 1.7 % of their body weight. This effect is due to the fact that alpha lipoic acid has the ability to reduce sugar.
Can side effects occur when taking alpha lipoic acid?
Alpha lipoic acid is considered to be very well tolerated. Therefore, when adhering to the recommended dosages according to the Physicians' Desk Reference (PDR) there are no known side effects and no reports of overdoses.
However, there is evidence to suggest that high doses of alpha lipoic acid can contribute to an undersupply of thiamine. The side effects that occur here are allergic reactions such as hives, headaches, muscle cramps or skin rashes.
Recommended intake R-alpha lipoic acid:
- As a dietary supplement, take up to 3 capsules a day with plenty of water, preferably half an hour before meals.
- Dairy products should be avoided with these meals so as not to weaken the effectiveness of R-alpha lipoic acid.
Do not exceed the recommended daily intake.
Food supplements are not a substitute for a balanced and varied diet.
Store in a cool, dry place away from light. Keep out of the reach of small children.
Composition R-alpha lipoic acid:
R-alpha lipoic acid, hydroxypropyl methylcellulose (capsule shell)
Quantities per capsule:
R-alpha lipoic acid |
400 mg |

glutenfrei

laktosefrei

ohnegelatin

vegan
Is it the stabilized form of R-alpha lipoic acid?
Yes, it is the body-identical and stabilized form of R-alpha lipoic acid.
Is your product the pure R-form, or does it also contain the S-form of alpha lipoic acid?
Herbano uses only 100% pure R-alpha lipoic acid.
How quickly do alpha lipoic acid capsules work?
As alpha lipoic acid is both fat and water soluble, it can be optimally absorbed in the gastrointestinal tract. It is therefore distributed directly throughout the entire organism.
Is R-alpha lipoic acid soluble in water?
Yes, it is both water- and fat-soluble.
Does R-Alpha Lipoic Acid Capsules contain magnesium stearate?
No, our stabilized form of R-alpha lipoic acid no longer contains magnesium stearate.
Can alpha lipoic acid be taken with milk or dairy products?
No, R-alpha lipoic acid should not be taken with dairy products. The reason for this is that the medium-chain fatty acids contained in dairy products make the absorption of R-alpha lipoic acid more difficult.
To ensure the highest possible bioavailability, R-alpha lipoic acid should not be taken later than half an hour before a meal to be on the safe side.
Important: Iron and magnesium supplements as well as milk (high calcium content) should not be taken together with alpha-lipoic acid, as the active ingredient likes to form compounds with metals (so-called metal chelator) and the effect can be weakened as a result.
Should alpha lipoic acid be taken with meals?
As many meals contain dairy products, which inhibit the bioavailability of alpha lipoic acid, we recommend not taking the product with meals to be on the safe side.
Sources (in English):
Ziegler, D., Low, P. A., Freeman, R., Tritschler, H. & Vinik, A. I. (2016, March). Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial. Journal of diabetes and its complications, 30(2):350-6. doi: 10.1016/j.jdiacomp.2015.10.018
Garcia-Alcala, H., Santos Vichido, C. I., Islas Macedo, S., Genestier-Tamborero, C. N., Minutti-Palacios, M. Hirales Tames, O. et al. (2015). Treatment with α-Lipoic Acid over 16 Weeks in Type 2 Diabetic Patients with Symptomatic Polyneuropathy Who Responded to Initial 4-Week High-Dose Loading, Journal of diabetes research, 2015:189857. doi: 10.1155/2015/189857
Dy, S. M., Bennett, W. L., Sharma, R., Zhang, A., Waldfogel, J. M., Nesbit, S. A. et al. (2017, March) Preventing Complications and Treating Symptoms of Diabetic Peripheral Neuropathy [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); Report No.: 17-EHC005-EF
Várkonyi, T., Körei, A., Putz, Z., Martos, T., Keresztes, K., Lengyel, C. et al. (2017, October) Advances in the management of diabetic neuropathy, Minerva Medica, 108(5):419-437. doi: 10.23736/S0026-4806.17.05257-0
Scaramuzza, A., Giani, E., Redaelli, F., Ungheri, S., Macedoni, M., Giudici, V. et al. (2015) Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial, Journal of diabetes research, 2015:474561. doi: 10.1155/2015/474561
Packer, L., Witt, E. H. & Tritschler, H. J. (1995, August). alpha-Lipoic acid as a biological antioxidant. Free Radical Biology & Medicine, 19(2):227-50
Evans, J. L. & Goldfine, I. D. (2000). Alpha-lipoic acid: a multifunctional antioxidant that improves [von Google zensierter Begriff] sensitivity in patients with type 2 diabetes. Diabetes Technology & Therapeutics, 2(3):401-13, doi: 10.1089/15209150050194279
Desideri I., Francolini G., Becherini C., Terziani F., Delli Paoli C., Olmetto E. et al. (2017, March). Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera®) for chemotherapy-induced peripheral neuropathy management, a prospective study. Med Oncol, 34(3):46, doi: 10.1007/s12032-017-0907-4
Zhang X., Zhang Y., Gao X., Wu J., Jiao X., Zhao J. et al. (2014, May). Investigating the role of backward walking therapy in alleviating plantar pressure of patients with diabetic peripheral neuropathy. Arch Phys Med Rehabil, 95(5):832-9, doi: 10.1016/j.apmr.2014.01.003
Guo Y., Jones D., Palmer J. L., Forman A., Dakhil S. R., Velasco M. R. et al. (2014, May). Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. Support Care Cancer, 22(5):1223-31, doi: 10.1007/s00520-013-2075-1
Jo S. H., Kim S. A., Kim H. S., Han S. J., Park W. J. & Choi Y. J. (2013). Alpha-lipoic acid for the prevention of contrast-induced nephropathy in patients undergoing coronary angiography: the ALIVE study - a prospective randomized trial. Cardiology, 126(3):159-66, doi: 10.1159/000353812
Pop-Busui R., Stevens M. J., Raffel D. M., White E. A., Mehta M., Plunkett C. D. et al. (2013, August). Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in type 1 diabetes: a randomised controlled trial. Diabetologia, 56(8):1835-44, doi: 10.1007/s00125-013-2942-9
Ibrahimpasic K. (2013). Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Med Arch, 67(1):7-9.
Bertolotto F. & Massone A. (2012, March). Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. Drugs R. D, 12(1):29-34, doi: 10.2165/11599200-000000000-00000
Ziegler D., Low P. A., Litchy W. J., Boulton A. J., Vinik A. I., Freeman R. et al. (2011, September). Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care, 34(9):2054-60, doi: 10.2337/dc11-0503
Sadykova H. G. & Nazhmutdinova D. K. (2009, January-February). [Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with diabetic autonomic neuropathy]. Lik Sprava, (1-2):22-8.
Statsenko M. E., Poletaeva L. V., Turkina S. V., Apukhtin A. F. & Dudchenko G. P. (2008). [Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy]. Ter Arkh, 80(10):27-30.
Volchegorskii I. A., Alekseev M. N., Volchegorskaia M. I. & Rassokhina L. M. (2008). [Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome]. Klin Med (Mosk), 86(10):52-9
Huang E. A. & Gitelman S. E. (2008, June). The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. Pediatr Diabetes, 9(3 Pt 2):69-73, doi: 10.1111/j.1399-5448.2007.00342.x
Liu F., Zhang Y., Yang M., Liu B. Shen Y. D., Jia W. P. et al. (2007, October). [Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study]. Zhonghua Yi Xue Za Zhi, 87(38):2706-9.
Magis D., Ambrosini A., Sándor P., Jacquy J., Laloux P. & Schoenen J. (2007, January). A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache, 47(1):52-7, doi: 10.1111/j.1526-4610.2006.00626.x
Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A. et al. (2006, November). Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care, 29(11):2365-70, doi: 10.2337/dc06-1216
Negrisanu G., Rosu M., Bolte B., Lefter D. & Diabelea D. (1999, July-September). Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy. Rom J Intern Med, 37(3):297-306
Tankova T., Koev D. & Dakovska L. (2004). Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). Rom J Intern Med, 42(2):457-64
Jedynasty K., Łomińska T., Toruńska K. & Kasperska-Czyzykowa T. (2003, August). [Acute painful neuropathy at the initial period of effective insulin therapy]. Pol Arch Med Wewn, 110(2):885-90
Femiano F., Scully C. & Gombros F. (2002, December). Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy. Int J Oral Maxillofac Surg, 31(6):625-8, doi: 10.1054/ijom.2002.0276
Haak E., Usadel K. H., Kusterer K., Amini P., Frommeyer R., Tritschler H. J. et al. (2000). Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. Exp Clin Endocrinol Diabetes, 108(3):168-74, doi: 10.1055/s-2000-7739
Androne L., Gavan N. A., Veresiu I. A. & Orasan R. (2000, March-April). In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo, 14(2):327-30
Ziegler D. & Gries F. A. (1997, September). Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes, 46 Suppl 2:S62-6.